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Objective: To analyze the vaccination status of SARS-CoV-2 in children, and explore the relationship between SARS-CoV-2 vaccination and COVID-19 in children. Methods: A retrospective study was conducted to analyze the clinical data of 335 cases of SARS-CoV-2 Omicron variant infection from February 15, 2022 to March 18, 2022 in Shenzhen Third People's Hospital. Results: Among 335 children with SARS-CoV-2 infection, 174(51.9%) cases were vaccinated with the SARS-CoV-2 vaccine;33(31.4%) cases were vaccinated in the 3-<6 years old group;141(61.3%) cases were vaccinated in the 6-<14 years old group. There was a statistically significant difference in the proportion of SARS-CoV-2 vaccination between the 6-<14 years old group and the 3-<6 years old group (X2=26.1, P < 0.05). In the study cohort, 3-<6 years old group and 6-<14 years old group, there was no significant difference in the incidence of COVID-19 in the vaccinated group compared with the unvaccinated group (P > 0.05). In the study cohort, the proportion of confirmed cases of 1 dose of SARS-CoV-2 vaccine and 2 doses or more of SARS-CoV-2 vaccine was 89.5% (68 cases) and 77.6% (76 cases), respectively;in the 6~<14 years old group, the proportion of confirmed cases of 1 dose of SARS-CoV-2 vaccine and 2 doses or more of SARS-CoV-2 vaccine was 90.0% (54 cases) and 76.5% (62 cases), respectively;the differences were statistically significant (X2=4.264, P < 0.05;X2=4.279, P < 0.05). The IgG levels of 18.28 (6.61, 55.2) AU/mL and 58.3 (25.85, 131.41) AU/mL in the study cohort who were vaccinated for 1 dose, 2 doses and more, respectively;the IgG levels of 20.13 (8.33, 44.33) AU/mL and 56.57 (25.85, 150.07) AU/mL in the 6~<14 years old group who were vaccinated for 1 dose, 2 doses and more, respectively;and the differences were statistically significant (Z=-4.37, P < 0.05;Z=-3.96, P < 0.05). Conclusions: Children who received 2 doses of SARS-CoV-2 vaccine have a lower incidence of COVID-19 and higher levels of SARS-CoV-2 antibodies compared with who received 1 dose. It is recommended that children are advised to be vaccinated against the COVID-19.
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The COVID-19 vaccines provide a high degree of protection against severe disease, hospitalisation, and death. However, no vaccine claimed 100% effectiveness and it is expected that a small proportion of vaccinated individuals may develop a breakthrough infection due to individual differences, virus variants and other factors. We conducted an epidemiological investigation and analysis of an imported case who had finished four doses of vaccination, and in order to provide a relevant reference for regular epidemic prevention and control in the post-pandemic era.
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Respiratory mucosal immune system is the body's first line of defense against infection. Since the outbreak of novel coronavirus disease 2019 (COVID-19) in 2019, nasal mucosal immune vaccine, with its ability to induce cellular, humoral and mucosal triple immune responses, has become a research hotspot. This article focuses on novel coronavirus, with an understanding of its structure and pathogenesis, a brief introduction to the immune mechanism of nasal mucosa, a summary of the different types of nasal mucosal immune vaccines and their clinical research, aiming to provide some theoretical reference for the development of new vaccines, and exploration of the best methods and strategies to combat COVID-19.
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Background: The outbreak of coronavirus disease 2019 (COVID-19) was declared by the World Health Organization (WHO) as a COVID-19 pandemic on March 11, 2020. Therefore, the availability of vaccines will help develop immunity and protect people from this pandemic. The present systematic study examined knowledge, attitudes, and willingness of adolescents towards COVID-19 vaccine in Bangkok, Thailand. Objectives: The objective of the study was to evaluate the knowledge, attitudes, and willingness toward COVID-19 vaccine of key stage 4A-5 students at Satit Prasarnmit International Programme in Bangkok towards COVID-19 vaccine. Materials and Methods: The study was conducted using an online questionnaire. A total of 136 students participated. Knowledge, attitudes, and willingness of adolescents toward the COVID-19 vaccine were assessed. Differences between outcomes and socio-demographic characteristics of participants were analyzed through independent t-tests and the ANOVA. The level of willingness to vaccinate against COVID-19 was analyzed by a generalized linear model. Results: Students revealed moderate knowledge about COVID-19, correctly answering 11.08 out of 15 points (SD = 1.74), a low level of attitudes toward COVID-19 vaccine 8.49 out of 15 points (SD = 2.51), and low level of willingness to vaccinate against COVID-19 vaccine 2.29 out of 5 points (SD = 1.26), in total of 35 points (28 questions). There are statistically significant positive correlations shown between attitude towards COVID-19 vaccine and the level of willingness to vaccinate against COVID-19 vaccine (I2 = 0.384, P < 0.01%). Conclusion: This study revealed students in Satit Prasarnmit International Programme had moderate knowledge towards COVID-19, negative attitudes toward COVID-19 vaccine and low willingness to vaccinate against COVID-19. Furthermore, it indicates that there is a casual relationship between attitudes toward COVID-19 vaccine and the willingness of individuals to be vaccinated against COVID-19 vaccine. Thus, attitude toward COVID-19 vaccine acts as a major predictive factor toward the willingness to vaccinate against COVID-19 vaccine. Therefore, to increase peopleA's willingness to be vaccinated against COVID-19 vaccine, it is necessary to increase peopleA's attitude toward COVID-19 vaccine.
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Objective: The present study aimed to assess the attitude and perception of Kabul city's residents toward COVID-19 vaccines hesitancy and acceptance. Methods: Applying a cross-sectional study design, the data was collected from 665 participants in Kabul city using a predesigned validated questionnaire. For statistical analysis, Spearman correlation, chi-square, and logistic regression techniques were used. Results: Although the vaccine availability was limited for the public during the survey period, 70.5% of the participants were willing to receive COVID-19 vaccines. Meanwhile, 49.2% participants were concerned about the COVID-19 vaccines side effects. The presence of positive COVID-19 cases among family members and friends (OR: 2.7), presence of fears during COVID-19 pandemic (OR: 4.4) and beliefs that vaccine has important and vital role in people's protection against COVID-19 (OR: 5.3), increase the likelihood of vaccine acceptance among the participants. On the other hand, participant's mistrust of the safety of COVID-19 vaccines (OR: 0.21) and disbelief on ministry of public health "MoPH" advice about COVID-19 vaccine safety and efficiency (OR: 0.27) decrease the odds of COVID-19 vaccine acceptance among the respondents. In addition, a strong correlation was found between vaccine attitude and vaccine acceptance scales (Spearman p=0.52, p<0.001). Conclusion: Although majority of the participants were willing to receive the COVID-19 vaccines, due to high level of participant's concerns about COVID-19 vaccines-related side effects, a great proportion of the respondents were hesitate to receive the COVID-19 vaccines. Accordingly, public awareness about COVID-19 vaccines must be increased to counteract incorrect and misleading propaganda about vaccination and immunization.
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This study aimed to find out the level of stress and coping methods among elderly in Sulaimanya city during the pandemic COVID-19. Through the snowballing sampling method, 394 elders were included to this study. After validation, two scales were used in this study;stress subscale from Depression, Anxiety and Stress Scale (DASS-21) and a culture-bound scale for determining coping methods. The results of this study showed that participants experienced a mild level of stress. Male participants, elders who live with their family, unvaccinated elders, physically passive elders have had higher stress level than female, elderly home, vaccinated, physical active elders. The findings also indicated that spiritual connection was the most common coping method used by the sample. Results of this study are the first and foremost way to share elder's unexpressed messages;it also can be a way for verbalizing their unspoken feelings. These results may also inform the elder's caregivers that elder's stress level and illness anxiety was not very high, strengthening their social support and spiritual connection may help them to reduce their distress into a lesser degree.
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The current monkeypox outbreak is a public health emergency of international concern and is coming in the wake of the SARS-CoV-2 pandemic. Human monkeypox is a viral zoonotic infection caused by monkeypox virus, an enveloped double-stranded DNA virus of the genus Orthopoxvirus and family Poxviridae that also contain smallpox, cowpox, Orf, and vaccinia viruses. Online databases including PubMed, Google Scholar and Web of Science were searched to obtain relevant publications on the epidemiology, treatment, vaccines and the economic impacts of the current monkeypox (Mpox) outbreak.
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Shingles is a viral skin disease caused by the Varicella Zoster virus. We report varicella zoster virus reactivation in three long-time athletes after vaccination with a COVID-19 mRNA vaccine. The three athletes had no evidence of immunosuppressive conditions or other illnesses, and all three did not suffer from COVID-19. The first patient is a 21-year-old athlete with an 8-year sports career. He developed shingles four days after being vaccinated against COVID-19. The second athlete is 20 years old and has been actively involved in fitness for ten years. He was diagnosed with herpes zoster three days after the vaccination. The third athlete is 23 years old and has been actively involved in sports and fitness since the age of 6;he was diagnosed 4 days after the vaccination against COVID-19. All three were diagnosed by a dermatologist. Discussion: The relationship between the development of herpes zoster after the administration of a vaccine against COVID-19 has been the subject of many studies worldwide, but the occurrence of herpes zoster after Covid-19 vaccination in athletes is described for the first time. Our team did not find a report of a case of an athlete with herpes zoster after vaccination for COVID-19 anywhere, which motivated us to describe the above three cases.
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Background: "Covishield" and "Covaxin" were the two vaccines which were approved for emergency use in India. As there is uncertainty regarding these vaccines, this study aimed to estimate the proportion of acceptance of vaccination against COVID-19 in West Bengal;to identify the possible barriers of vaccine acceptance prevalent among the study population and;to find out the association of acceptance of COVID-19 vaccination with the socio-demographic and other predictor variables. Methods: Oobservational study with cross sectional design was conductedon 294 participants in Muchisa, Budge Budge II and Ward No. 81 of Borough 10, Kolkata Municipal Corporation (KMC) selected by Stratified Random Sampling in 2021 using a predesigned, pretested and structured schedule. The statistical analysis was done using Microsoft Office Excel 2007 and Statistical Package for the Social Sciences Version 16.0. The data were explored using Pearson's chi-square test and logistic regression. A p-value of <0.05 was considered significant. Results: The potential acceptance of Covid-19 vaccination was 59.5% with higher adoption in urban population. The most potential barrier in acceptance of vaccine was "fear of side effects". Higher level of education and history of Covid-19 in the locality were associated with higher acceptance of the vaccination in both the urban and rural areas. Conclusion: A study emphasized on the need for mass campaigns and other behavior change communication activities for addressing the myths surrounding the disease and the newer vaccines and hence improving the currently low vaccine acceptance.
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Undoubtedly, vaccination can be one of the promising approaches to control infectious diseases such as the COVID-19 pandemic. Inactivated viral vaccines have a history of "vaccine-induced enhanced disease", which may occur when neutralizing antibodies bind to viral antigens without blocking or clearing the infection. This can cause additional inflammation through the mechanisms described for other respiratory pathogens and lead to acute respiratory distress syndrome. Since the structure and function of SARS-CoV-2 glycoproteins are well known, vaccine manufacturers appear to be careful when inactivating the virus to completely inactivate and maintain the viral epitopes necessary for protective immune induction. It seems that caution should be taken in the usage of inactivated vaccines in children to ensure they are safe and efficacious, vaccinated children should be well monitored and any symptoms should be reported immediately.
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Objective: This study included participants from Hacettepe University 4th, 5th, and 6th-grade students of Medical School and 4th and 5th-grade students of Dental School;and aimed to evaluate the general health status, COVID-19 history, vaccination status, and SARS-CoV-2 antibody levels of the participants to support their physical and social health, during the pandemic period. Methods: A prospective cohort study was conducted with an integrated, matched, nested case-control study. Sociodemographic characteristics, life habits, COVID-19 history, vaccination status, compliance with mask-distance-hygiene rules, and risks (if any) for COVID-19 were inquired via online questionnaires. Physical examinations, complete blood count, biochemistry tests, and anti-SARS-CoV-2 anti-spike antibody tests were conducted for all consenting participants. All analyses were established using depersonalized data. Results: Of the 778 participants completing the baseline visit in June-July 2021, the percentages of those vaccinated with at least one, two, and three/more doses of COVID-19 vaccine were 99.1%, 98.0%, and 11.7%, respectively;one had four doses. The median (minimum-maximum) time since the last vaccination was 134 (34-166) days for those vaccinated with two doses [CoronaVac (Sinovac Life Sciences, Beijing, China)] and 25 (14-56) days for those vaccinated with three doses [two doses of CoronaVac and a last dose of Pfizer-BioNTech mRNA vaccine (ComirnatyR). The third dose was applied at a median of 164 (151-202) days after the second dose, and all were heterologous in type. The median (minimum-maximum) antibody level for the overall group was 53.55(0-5680) BAU/mL: 47.19 BAU/mL in those who received two doses, with a more than 100 times increase after a third dose (4943.64 BAU/mL). Of the 522 participants followed up to October 1, 2021, 6 PCR-positive symptomatic participants were diagnosed with COVID-19: the incidence rate was 4/1000 person-months. Conclusion: A 100-fold neutralizing antibody level following the third dose demonstrated the importance of a booster dose. Given the time lag between doses, antibody measurements of BioNTech recipients should be repeated in the upcoming months. Booster selection should involve antibody level, variant sensitivity of the vaccine, and individual characteristics of the recipient.
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Objective: Vaccines are one of the promising approaches to control the pandemic. The aim of this study, which was conducted on healthcare workers who previously were or were not infected with COVID-19, was to evaluate the undesirable effects that developed after the CoronaVac (Sinovac Life Sciences, Beijing, China). Methods: Volunteers who were administered the first dose of inactivated CoronaVac vaccine between January 14-24, 2021, were included in this retrospective study. Demographic information was obtained from the questionnaire results and from the data of the applications made due to side effects. Results: 911 healthcare workers, 232 of whom had a history of COVID-19 were included in the study. The mean age of those with a history of COVID-19, was 36 (20-66), and 33.6% were men. 26.7% were doctors, 34.9% were nurses, 155 (66.8%) worked in internal and 62 (26.7%) in surgical units. There was no significant difference between the two groups regarding age, gender, task, and the departments they worked in. Comorbidities were present in 25.9% of the group with a history of COVID-19;the most common disease was asthma (5.6%). Allergy history was 4.3% in the group with COVID-19 and 7.8% in the other group (p=0.070). The incidence of post-vaccine adverse events (62.9%) was higher in those with a history of COVID-19 than in those without (57.1%). The most common adverse event was a headache, and it was significantly higher in the group who had COVID-19 compared to those who had not (36.6% vs. 27.7%;p=0.01). Conclusion: In our study, we observed that the rates of undesirable effects after vaccination were high in individuals with a history of COVID-19. Although it is thought that this situation may be related to the developing antibody response rates, the insufficient number of cases and the lack of determination of the antibody response after infection and vaccination are a disadvantage of the study.
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Background: The COVID-19 pandemic shook the world, claimed a lot of lives, incapacitated many, and forced majority of the world into a lockdown. Vaccination is the key strategy to tackling the virus. Objectives: To ascertain the level of vaccination and the difficulties associated with vaccination, among clinical medical students in Enugu, South-East Nigeria. Materials and Methods: A multistage sampling was used to select 160 respondents while questionnaires (hard and soft copy) were administered to the participants. The IBM Statistical Package for the Social Sciences was used for data entry and data analysis. Results: There was a poor (16.3%) knowledge, negative perception (66.3%), and poor uptake of the COVID-19 vaccine (20.6%). There were statistically significant relationships between vaccination status, knowledge of vaccine, age, and perception of the vaccine (P=0.000) as well as between level of training and vaccine perception (P=0.03). Conclusion: There was very low level of COVID-19 vaccination in the study population that may be attributable to the low knowledge of the vaccine and the high negative perception. The rush to development of the vaccine, possible side effects, and possible long-term complications may be contributory to the poor uptake of the COVID-19 vaccine among the study respondents.
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Purpose: The nutritional and anthropometric status can be essential in determining their immune response to vaccines. The purpose of this paper was to investigate the association between diet quality and anthropometric indices with the side effects of the Pfizer-BioNTech COVID-19 vaccine and the SARS-CoV-2 immunoglobulin G titer among Kurdish adults. Design/methodology/approach: This cross-sectional survey-based study was conducted between December 2021 and February 2022. This paper included data on 115 adults, 20-89 years old, from the Kurdistan region. Dietary information was collected using a short food frequency questionnaire, and diet quality was assessed using a plant-based healthy diet score. A blood test was performed to measure the SARS-CoV-2 immunoglobin G (IgG) titer after the vaccination's first and second doses. Findings: Overweight and obese subjects reported more local pain, myalgia, headache, local bruising and local reactions after receiving the first dose of the vaccine (p = 0.04). People on a less healthy diet reported more local pain, myalgia and headache (p = 0.04) and more local bruising and reactions (p = 0.01) after receiving the second dose of the vaccine. On the other hand, the authors observed that those with healthy dietary habits had more IgG titer after the first and second doses of vaccination than those with less healthy dietary habits (p = 0.001). Originality/valueThe results showed that participants with a healthy diet and normal weight status had fewer side effects of the Pfizer-BioNTech COVID-19 vaccine than obese people and those with a less healthy diet.
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Objective: Aim of study's determine frequency of hesitations of parents to COVID-19 vaccinate their children and parents the behaviors of take COVID-19 public health measures(PHM) for their children who applied to a university hospital in Turkey. Methods: This descriptive study is study of parental COVID-19 vaccine hesitancy and PHM in parents with children aged 5-12 years admitted to university hospital in Turkey, January-February 2022. Participants' sociodemographic, COVID-19 infection and vaccinations characteristics, status of parents taking PHM, COVID-19 Fear Scale are independent variables. Student's t test, ANOVA, chi-square test in univariate analyses, logistic-linear regression models in multivariate analyzes are used. Type-1 error value is 0.05. Analyzes are made using SPSS23.0. Results: Parents' mean age's 37.1+or-6.4, 68.7% of them female. Children's mean age's 8.5+or-2.3, 53.8% of them male. 17.9% of parents consider their knowledge of protection from COVID-19 and vaccines minimally sufficient/insufficient, 28.7% of them have negative attitude towards PHM for their children. 48.8% of parents have hesitations their children vaccination. As multiple analysis's result;fathers who've never been vaccinated, increase risk of hesitations 6.21 times (OR: 6.21;95%CI=2.16-17.82);parent's negative attitude towards PHM increases risk of hesitations 2.69 times (OR: 2.69;95%CI=1.35-5.35);each unit increase in mother's PHM behavior score affects hesitations 0.89 times (OR: 0.89;95%CI=0.84-0.95). While it's found that father's PHM behavior score had the most effect on parent's PHM behavior score, COVID-19 Fear Scale score had the least effect. Conclusion: Nearly one every two parents have COVID-19 vaccine hesitancy for their children. Fathers are main actors for taking PHM for COVID-19, so fathers as well as mothers should be considered target persons for children COVID-19 vaccine.
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IMMUNION (Improving IMMunisation cooperation in the European UNION) is a European project having the objective to support vaccine strategies. The project (active from April 2021 to March 2023) has contributed to improve knowledge on vaccines and vaccinations among health professionals and the information circulation in different target groups, through a multistakeholder collaboration including institutions, associations and media. The IMMUNION consortium has been focusing on activities of survey, professional training and communication, even with the aim to sustain visibility and role of the Coalition for Vaccination. In particular, ISS has coordinated the Work Package on finalising vaccine communication tools to increase vaccination compliance in target communities.
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Background: Coronavirus disease 2019 (COVID-19) or Coronavirus disease 2019 has rapidly affected all aspects of life around and become a major threat to public health around the world. One of the most important actions that need to be taken to stop the pandemic is vaccinations. Managing the COVID-19 pandemic in the long term, unwillingness to receive vaccinations, and negative attitudes toward vaccines are major barriers. Objectives: The objective of the study is to assess willing of Thai adolescents to get vaccinated against COVID-19 among high school students in Sacred Heart Convent School of Bangkok. Materials and Methods: The study was conducted using a questionnaire. A total of 80 students participated. Knowledge about COVID-19 and COVID-19 vaccine, Risk Perception of COVID-19 infection, and Confidence in the government in handling the pandemic. Independent t-test and ANOVA were used to analyze differences between outcomes and sociodemographic. Attitudes toward vaccination were analyzed by a generalized linear model. Results: This study showed that the vaccine acceptance rate was 15% and vaccine refusal was 85%. 15% of female participants accepted to be vaccinated against COVID-19 while all-male participants refused to be vaccinated against COVID-19. In the age of 17 participants, 6.25% showed the highest willingness to be vaccinated. Of the students who did not vaccinate Influenza 13.75% accepted to be vaccinated against COVID-19. Of the students who live in urban areas, 51.25% and single house 66.25% refuse to be vaccinated against COVID-19 respectively. Conclusion: This study indicates confidence in the government in handling the pandemic influenced the willingness to vaccinate against COVID-19.
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Introduction: The emerging respiratory illness caused by SARS-CoV-2 has posed the threat to human life across the globe. Various physical measures applied to curb the spread of the virus in initial phase of pandemic but high level of immunity by vaccination is an effective strategy to reduce the morbidity and mortality. To achieve this parent's willingness is important for vaccination of children. Objectives: To study the parent's willingness and associated factors to vaccinate the children with Covid-19 vaccine. Material & Methods: The cross sectional study conducted in the month of July 2022. A confidential interview of 300 parents visited to OPD was taken. Information obtained about socio-demography, routine immunization and comorbidity in children, parents COVID-19 vaccination, COVID-19 infection and hospitalization in family members and willingness for children's covid-19 vaccination. Results: Out of 300 parents around 253(84.3%) parentswere willing, 10(3.3%) not willing and 37(12.3%) not sure about children's vaccination. hospitalization of family members, parental vaccination against Covid-19, vaccination of siblings > 12 years, parents having 1- 2 children were significantly associated with willingness. Conclusion: Counselling of parents to relieve the anxiety is needed, communicating clear information about vaccination and expected side effects of the vaccine, provision of reliable source of information like family physician, health care workers.
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Objective: In this study, the effect of having had coronavirus disease-2019 (COVID-19) disease on anti-vaccination was investigated. Material and Methods: The study was conducted between February 2022-August 2022 in the COVID chest diseases clinic in our hospital. The cases who were COVID-19 vaccine hesitancy and not vaccinated against COVID-19 hospitalized in our clinic were included in the study. The level of anti-vaccination of the cases was measured with the Vaccine Hesitancy Scale (VHS). In addition, demographic informations such as age, gender, educational status, marital status, number of people living in the household, average monthly income, smoking history, and additional chronic diseases were recorded. Routine radiological and laboratory examinations, follow-up times in the clinic, and treatment results were recorded for cases like all patients hospitalized in our COVID chest diseases clinic. Results: 46 cases were included in the study. The mean age of the cases was 54.63+or-14.81 years, 24 (52.1%) were female. VHS was applied to all cases at the time of hospitalization. Since 6 cases were referred to the intensive care unit due to respiratory failure, the second VHS could not be applied to these cases, and these 6 cases were excluded from the study. A 2nd VHS was performed in the remaining 40 patients just before discharge. Each question score, A-B-C section score and total scale score were compared for the pre-COVID-19 and post-COVID-19 cases. While the VHS total score before COVID-19 infection was 36.48+or-7.36, the post-COVID-19 total score was found to be 25.65+or-9.10, a statistically significant decrease was observed (p < 0.001). It was observed that the mean scores of A-B-C decreased statistically in all sections (p < 0.001). Conclusion: As a result of our study, we found that the degree of anti-vaccine resistance decreased after the patients who were against the COVID-19 vaccine had the disease. As a result of our study, we found that the degree of COVID-19 vaccine hesitancy of patients decreased after they had the disease. We believe that conducting similar studies and sharing their results through mass media, can change the perspective of vaccine hesitancy individuals in society on this situation, especially during pandemic periods.
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In 2019, a new coronavirus (COVID-19) was discovered in Wuhan, China, which soon spread all over the world. The main hallmark of the disease includes fever, diarrhea, vomiting, and dry cough with dyspnea in half of the patients and acute respiratory distress syndrome (ARDS). Currently, no definitive treatment or prevention therapy exists for COVID-19 but scientists and researchers all over the world are relentlessly working to understand COVID-19 to discover novel therapeutic tools and vaccines. Today, photodynamic therapy (PDT) has been investigated as a noninvasive therapy for the treatment of this pandemic and was able to increase the healing process with the help of appropriate photosensitizers by targeting the pathogen inside the patient's body.